| Actor/Actress |
Role |
| Scott Bakula |
Capt. Jonathan Archer / ... 97 episodes, 2001-2005 |
| John Billingsley |
Dr. Phlox 97 episodes, 2001-2005 |
| Jolene Blalock |
Sub-Cmdr. T'Pol / ... 97 episodes, 2001-2005 |
| Dominic Keating |
Lt. Malcolm Reed / ... 97 episodes, 2001-2005 |
| Anthony Montgomery |
Ensign Travis Mayweather / ... 97 episodes, 2001-2005 |
| Linda Park |
Ensign Hoshi Sato / ... 97 episodes, 2001-2005 |
| Connor Trinneer |
Cmdr. Charles 'Trip' Tucker III 97 episodes, 2001-2005 |
| Solomon Burke Jr. |
Ensign Billy 1 episode, 2001-2005 |
| Vaughn Armstrong |
Adm. Maxwell Forrest / ... 18 episodes, 2001-2005 |
| Gary Graham |
Ambassador Soval / ... 12 episodes, 2001-2005 |