| Actor/Actress | Role | 
| Scott Bakula | Capt. Jonathan Archer / ... 97 episodes, 2001-2005 | 
| John Billingsley | Dr. Phlox 97 episodes, 2001-2005 | 
| Jolene Blalock | Sub-Cmdr. T'Pol / ... 97 episodes, 2001-2005 | 
| Dominic Keating | Lt. Malcolm Reed / ... 97 episodes, 2001-2005 | 
| Anthony Montgomery | Ensign Travis Mayweather / ... 97 episodes, 2001-2005 | 
| Linda Park | Ensign Hoshi Sato / ... 97 episodes, 2001-2005 | 
| Connor Trinneer | Cmdr. Charles 'Trip' Tucker III 97 episodes, 2001-2005 | 
| Solomon Burke Jr. | Ensign Billy 1 episode, 2001-2005 | 
| Vaughn Armstrong | Adm. Maxwell Forrest / ... 18 episodes, 2001-2005 | 
| Gary Graham | Ambassador Soval / ... 12 episodes, 2001-2005 |