| Actor/Actress |
Role |
| Bob Hoskins |
Eddie Valiant |
| Christopher Lloyd |
Judge Doom |
| Joanna Cassidy |
Dolores |
| Charles Fleischer |
Roger Rabbit/Benny The Cab/Greasy/Psycho (voice) |
| Kathleen Turner |
Jessica Rabbit (voice) (uncredited) |
| Stubby Kaye |
Marvin Acme |
| Alan Tilvern |
R.K. Maroon |
| Richard LeParmentier |
Lt. Santino |
| Lou Hirsch |
Baby Herman (voice) |
| Betsy Brantley |
Jessica's Performance Model |
| Mel Blanc |
Bugs Bunny/Daffy Duck/Tweety Bird (voice) |
| Mae Questel |
Betty Boop (voice) |
| Frank Sinatra |
Singer |
| Richard Williams |
Droopy (voice) |
| Wayne Allwine |
Mickey Mouse (voice) |
| Frank Welker |
Dumbo (voice) |
| Mickie McGowan |
Mooing Cow/Flying Witch (voice) |
| Jack Angel |
Additional Voices (voice) |
| Nancy Cartwright |
Dipped Shoe (voice) |
| June Foray |
Wheezy/Lena Hyena (voice) |
| Joel Silver |
Raoul |
| Amy Irving |
Jessica Rabbit (singing voice) |
| Paul Springer |
Augie |
| Richard Ridings |
Angelo |
| Edwin Craig |
Arthritic Cowboy |
| Lindsay Holiday |
Soldier |
| Mike Edmonds |
Stretch |
| Morgan Deare |
Editor / Gorilla (voice) |
| Danny Capri |
Kid #1 |
| Christopher Hollosy |
Kid #2 |
| Jean-Paul Sipla |
Kid #3 |
| Laura Frances |
Blonde Starlet |
| Joel Cutrara |
Forensic #1 |
| Billy J. Mitchell |
Forensic #2 |
| Eric B. Sindon |
Mailman |
| Ed Herlihy |
Newscaster |
| James O'Connell |
Conductor |
| Eugene Gutierrez |
Teddy Valiant |
| April Winchell |
Mrs. Herman (voice) |
| Tony Anselmo |
Donald Duck (voice) |
| Mary T. Radford |
Hippo (voice) |
| Joe Alaskey |
Yosemite Sam / Foghorn Leghorn (voice) |
| David L. Lander |
Smart Ass (voice) |
| Fred Newman |
Stupid (voice) |
| June Foray |
Wheezy / Lena Hyena (voice) |
| Russi Taylor |
Birds / Minnie Mouse (voice) |
| Les Perkins |
Mr. Toad (voice) |
| Richard Williams |
Droopy Dog |
| Pat Buttram |
Bullet #1 |
| Jim Cummings |
Bullet #2 |
| Jim Gallant |
Bullet #3 |
| Tony Pope |
Goofy / Big Bad Wolf (voice) |
| Peter Westy |
Pinocchio (voice) |
| Cherry Davis |
Woody Woodpecker |
