| Actor/Actress |
Role |
| Will Ferrell |
Harold Crick |
| Maggie Gyllenhaal |
Ana Pascal |
| Dustin Hoffman |
Professor Jules Hilbert |
| Emma Thompson |
Karen Eiffel |
| Queen Latifah |
Penny Escher |
| Ricky Adams |
Junge |
| Denise Hughes |
Kronecker Bus Driver |
| Christian Stolte |
Young Boy's Father |
| Tony Hale |
Dave |
| Peggy Roeder |
Polish Woman |
| William Dick |
IRS Co-Worker #1 |
| Guy Massey |
IRS Co-Worker #2 |
| Martha Espinoza |
IRS Co-Worker #3 |
| T.J. Jagodowski |
IRS Co-Worker #4 |
| Peter Grosz |
IRS Co-Worker #5 |
| Tonray Ho |
IRS Co-Worker #6 |
| Danny Rhodes |
Bakery Employee #1 |
| Linara Washington |
Bakery Employee #2 |
| Helen Young |
Bakery Customer #1 |
| David Pompeii |
Bakery Customer #2 |
| David Wiegers |
Bakery Customer #3 |
| Jarrett Sleeper |
Bakery Customer #4 |
| Larry Neumann Jr. |
Homeless Man |
| John Mohrlein |
Man with Hose |
| Tom Hulce |
Dr. Cayly |
| Bruce Jarchow |
Commuter |
| Linda Hunt |
Dr. Mittag-Leffler |
| Kristin Chenoweth |
Book Channel Host |
| Keith Kupferer |
Demolition Foreman |
| Danny McCarthy |
Demolition Crew #1 |
| Tab Baker |
Demolition Crew #2 |
| Bryan Kelly |
ER Orderly |
| Whitney Sneed |
ER Nurse #1 |
| Celeste Pechous |
ER Nurse #2 |
| Christian Young |
ER Doctor #1 |
| Ray Kurut |
ER Doctor #2 |
| Michael Cook |
ER Doctor #3 |
| Cheryl Lynn Bruce |
Head ER Nurse |
| Ora Jones |
Banneker Press Receptionist |
| Will Clinger |
Accident Witness |
| Frank Caeti |
Accident Witness |
| Andrew Rothenberg |
Doctor Mercator |
| Bob Papenbrook |
Animal Footage Voice Over (voice) |
| Nathan Adloff |
Bakery Patron (uncredited) |
| Edy Cullen |
Business Women (uncredited) |
| Tim Krueger |
Business Man (uncredited) |
| Eli Goodman |
Augustus Chatman (uncredited) |
| Sia A. Moody |
Nurse #3 (uncredited) |
