| Actor/Actress |
Role |
| Sandra Bullock |
Scarlet Overkill (voice) |
| Jon Hamm |
Herb Overkill (voice) |
| Michael Keaton |
Walter Nelson (voice) |
| Allison Janney |
Madge Nelson (voice) |
| Steve Coogan |
Professor Flux / Tower Guard (voice) |
| Jennifer Saunders |
Reine Elizabeth II (voice) |
| Geoffrey Rush |
Narrator (voice) |
| Steve Carell |
Gru (voice) |
| Pierre Coffin |
Stuart, Kevin and Bob (voices) |
| Katy Mixon |
Tina (voice) |
| Michael Beattie |
VNC Announcer / Walter Jr. (voice) |
| Hiroyuki Sanada |
Sumo (voice) |
| Dave Rosenbaum |
Fabrice (voice) |
| Alex Dowding |
Royal Advisor (voice) |
| Paul Thornley |
News Reporter (voice) |
| Kyle Balda |
Additional Voices (voice) |
| Ava Acres |
Additional Voices (voice) |
| Sherry Lynn |
Additional Voices (voice) |
| Mickie McGowan |
Additional Voices (voice) |
| Carlos Alazraqui |
Additional Voices (voice) |
| Lori Alan |
Additional Voices (voice) |
| Daniel Barker |
Additional Voices (voice) |
| Bob Bergen |
Additional Voices (voice) |
| Melanie Bond |
Additional Voices (voice) |
| Jim Cummings |
Additional Voices (voice) |
| John Cygan |
Additional Voices (voice) |
| Brian T. Delaney |
Additional Voices (voice) |
| Bill Farmer |
Additional Voices (voice) |
| Keith Ferguson |
Additional Voices (voice) |
| Jess Harnell |
Additional Voices (voice) |
| Eve Karpf |
Additional Voices (voice) |
| John Kassir |
Additional Voices (voice) |
| Lewis Macleod |
Additional Voices (voice) |
| Danny Mann |
Additional Voices (voice) |
| Mona Marshall |
Additional Voices (voice) |
| Gary Martin |
Additional Voices (voice) |
| Laraine Newman |
Additional Voices (voice) |
| Andy Nyman |
Additional Voices (voice) |
| Alexander Polinsky |
Additional Voices (voice) |
| Jan Rabson |
Additional Voices (voice) |
| Christopher Ragland |
Additional Voices (voice) |
| Mindy Sterling |
Additional Voices (voice) |
| Tara Strong |
Additional Voices (voice) |
| Jim Ward |
Additional Voices (voice) |
| Colette Whitaker |
Additional Voices (voice) |
| James Daniel Wilson |
Additional Voices (voice) |
