| Actor/Actress |
Role |
| Tommy Lee Jones |
Kevin Brown, Agent Kay |
| Will Smith |
Agent Jay |
| Rip Torn |
Zed |
| Lara Flynn Boyle |
Serleena |
| Johnny Knoxville |
Scrad/Charlie |
| Rosario Dawson |
Laura Vasquez |
| Tony Shalhoub |
Jack Jeebs |
| Patrick Warburton |
Agent Tee |
| Jack Kehler |
Ben |
| David Cross |
Newton |
| Colombe Jacobsen-Derstine |
Hailey |
| Peter Spellos |
Captain Larry Bridgewater, The Motorman |
| Michael Rivkin |
the man with Harvey, the dog |
| Michael Bailey Smith |
Creepy |
| Lenny Venito |
New York guy |
| Howard Spiegel |
New York guy |
| Alpheus Merchant |
MIB guard |
| Jay Johnston |
the younger Pizza Parlor MIB agent |
| Joel McKinnon Miller |
agent |
| Rick Baker |
MIB Passport Control Agent |
| Martha Stewart |
Martha Stewart |
| Michael Jackson |
Agent M |
| Nick Cannon |
MIB Autopsy Agent |
| Jeremy Howard |
Bird Guy Alien / Postal Sorting Alien |
| Doug Jones |
Joey |
| Biz Markie |
Rapping Alien |
| Peter Graves |
Peter Graves |
| Linda Kim |
Ambassador Lauranna |
| Derek Mears |
Mosh Tendrils |
| Tim Blaney |
Frank the Pug (voice) |
| Derek Cecil |
Repairman Agent |
| Sean Rouse |
MIB Agent |
| Peter Spruyt |
MIB Customs Agent |
| Kevin Cotteleer |
MIB Customs Agent |
| Marty Belafsky |
MIB Customs Agent |
| Sid Hillman |
Agent Gee |
| Tom Whitenight |
MIB Agent C |
| Andre Blair |
Central Park Agent |
| Mary Stein |
Bird Lady Alien |
| Martin Klebba |
Family Child Alien |
| Denise Cheshire |
Family Mom / Locker Alien |
| Ernie Grunwald |
Young Postal Employee |
| Chloe Sonnenfeld |
Elizabeth, Young Girl at the Post Office |
| John Andrew Berton Jr. |
Split Alien Guy |
| William E. Jackson |
Eye Guy |
| Paige Brooks |
'Mysteries in History' Lauranna |
| Stephanie Kemp |
Neuralyzed Mother |
| Barry Sonnenfeld |
Neuralyzed Father |
| Brooke Bennett |
Neuralyzed Daughter |
| Michael Garvey |
Corn Face |
| Michael Dahlen |
Flesh Balls |
| Kevin Grevioux |
Pineal Eye |
| Sonny Tipton |
Dog Poop |
| Philip Goodwin |
Diner Guy |
| Greg Ballora |
Sleeble (voice) |
| Carl J. Johnson |
Gleeble (voice) |
| Thom Fountain |
Neeble (voice) |
| Brad Abrell |
Mannix (voice) |
| Richard Pearson |
Gordy (voice) |
