| Actor/Actress |
Role |
| Owen Wilson |
Lightning McQueen (voice) |
| Larry the Cable Guy |
Mater (voice) |
| Michael Caine |
Finn McMissile (voice) |
| Emily Mortimer |
Holley Shiftwell (voice) |
| John Turturro |
Francesco Bernoulli (voice) |
| Eddie Izzard |
Sir Miles Axlerod (voice) |
| Thomas Kretschmann |
Professor Z (voice) |
| Joe Mantegna |
Grem (voice) |
| Peter Jacobson |
Acer (voice) |
| Bruce Campbell |
Rod "Torque" Redline (voice) |
| Tony Shalhoub |
Luigi (voice) |
| Darrell Waltrip |
Darrell Cartrip (voice) |
| Guido Quaroni |
Guido (voice) |
| Brent Musburger |
Brent Mustangburger (voice) |
| Jason Isaacs |
Siddeley / Leland Turbo (voice) |
| David Hobbs |
David Hobbscap (voice) |
| Stanley Townsend |
Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice) |
| Lloyd Sherr |
Fillmore / Combat Ship (voice) |
| Paul Dooley |
Sarge (voice) |
| Michel Michelis |
Tomber (voice) |
| Sig Hansen |
Crabby (voice) |
| Franco Nero |
Uncle Topolino (voice) |
| Vanessa Redgrave |
The Queen / Mama Topolino (voice) |
| Bonnie Hunt |
Sally Carrera (voice) |
| Cheech Marin |
Ramone (voice) |
| Jenifer Lewis |
Flo (voice) |
| Michael Wallis |
Sheriff (voice) |
| Katherine Helmond |
Lizzie (voice) |
| John Ratzenberger |
Mack (voice) |
| Jeff Garlin |
Otis (voice) |
| Patrick Walker |
Mel Dorado (voice) |
| Lewis Hamilton |
Lewis Hamilton (voice) |
| Velibor Topic |
Alexander Hugo (voice) |
| John Mainieri |
J. Curby Gremlin (voice) |
| Brad Lewis |
Tubbs Pacer (voice) |
| Richard Kind |
Van (voice) |
| Edie McClurg |
Minny (voice) |
| Teresa Gallagher |
Mater's Computer (voice) |
| Jeff Gordon |
Jeff Gorvette (voice) |
| John Lasseter |
Additional Voices (voice) |
| Mark Winterbottom |
Frosty (voice) |
| Daisuke 'Dice' Tsutsumi |
Additional Voices (voice) |
| Fernando Alonso |
Fernando Alonso (voice) |
| Vitaly Petrov |
Vitaly Petrov (voice) |
| Jan Nilsson |
Flash (voice) |
| Memo Rojas |
Memo Rojas (voice) |
| Jacques Villeneuve |
Jacques Villeneuve (voice) |
| Sebastian Vettel |
Sebastian Vettel (voice) |
| Catherine Bolt |
Additional Voices (voice) |
| Jess Fulton |
Additional Voices (voice) |
| Sonoko Konishi |
Additional Voices (voice) |
| Gillian Bolt |
Additional Voices (voice) |
